English
    Lehrstuhl für Botanik I - Pflanzenphysiologie und Biophysik

    Publikationen

    2015

    Gao S, Nagpal J, Schneider MW, Kozjak-Pavlovic V, Nagel G, Gottschalk A. (2015) Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp. Nat Commun. 6:8046. doi: 10.1038/ncomms9046 (2015)

    2014

    Dawydow A., Gueta R., Ljaschenko D., Ullrich S., Hermann M., Fiala A., Langenhan T., Nagel G., Kittel R.J., (2014) Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications. Proc Natl Acad Sci USA. 111(38):13972-7

    2013

    Raffelberg S, Wang L, Gao S, Losi A, Gärtner W, Nagel G. (2013) A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacterium Microcoleus chthonoplastes PCC 7420. Biochem J; 455(3):359-65

    Hegemann P, Nagel G. (2013) From channelrhodopsins to optogenetics.EMBO Mol Med. 5(2):173-6. doi: 10.1002/emmm.201202387. Epub 2013 Jan 22.

    Ullrich S, Gueta R, Nagel G. (2013) Degradation of channelopsin-2 in the absence of retinal and degradation resistance in certain mutants. Biol Chem. 2013 Feb;394(2):271-80.

    2011

    Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A. (2011) Optogenetic long-term manipulation of behavior and animal development. PLoS. 6(4):18766.

    Yonehara K, Balint K, Noda M, Nagel G, Bamberg E, Roska B. (2011) Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature. 469(7330):407-10.

    Weissenberger S, Schultheis C, Liewald JF, Erbguth K, Nagel G, Gottschalk A. (2011) PACα--an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans. J Neurochem. 116(4):616-25.

    Stierl M, Stumpf P, Udwari D, Gueta R, Hagedorn R, Losi A, Gärtner W, Petereit L, Efetova M, Schwarzel M, Oertner TG, Nagel G, Hegemann P. (2011) Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem. 286(2):1181-8.

    2010

    Bamann C, Nagel G, Bamberg E. (2010) Microbial rhodopsins in the spotlight. Curr. Opin. Neurobiol. 20(5):610-6.

    Bamann C, Gueta R, Kleinlogel S, Nagel G, Bamberg E. (2010) Structural guidance of the photocycle of channelrhodopsin-2 by an interhelical hydrogen bond. Biochemistry. 49(2):267-78.

    2009

    Looser J, Schröder-Lang S, Hegemann P, Nagel G. (2009) Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha). Biol Chem. 390(11):1105-11.

    Radu I, Bamann C, Nack M, Nagel G, Bamberg E, Heberle J. (2009) Conformational Changes of Channelrhodopsin-2. J. Am. Chem. Soc. 131, 7313-7319.

    2008

    Caldwell JH, Herin GA, Nagel G, Bamberg E, Scheschonka A, Betz H. (2008) Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7. J Biol Chem. 283, 24300-24307.

    C. Bamann, T. Kirsch, G. Nagel, and E. Bamberg (2008) Spectral charcteristics of the photocycle of channelrhodopsin-2 and its implication for channel function. J Mol Biol. 375(3):686-694.

    2007

    F. Zhang, L.-P. Wang, M. Brauner, J.F. Liewald, K. Kay, N. Watzke, P.G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth (2007) Multimodal fast optical interrogation of neural circuits. Nature 446:633-639.

    Schröder-Lang, S., M. Schwärzel, R. Seifert, T. Strünker, S. Kateriya, J. Looser, M. Watanabe, U. B. Kaupp, P. Hegemann, G. Nagel (2007) Fast manipulation of cellular cAMP level by light in vivo. Nat Methods 4(1):39-42.

    2006

    Schroll C, Riemensperger T, Bucher D, Ehmer J, Voller T, Erbguth K, Gerber B, Hendel T, Nagel G, Buchner E, Fiala A. (2006) Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae. Curr Biol. 16(17):1741-7.

    Zimmermann D, Terpitz U, Zhou A, Reuss R, Müller K, Sukhorukov VL, Gessner P, Nagel G, Zimmermann U, Bamberg E. (2006) Biophysical characterisation of electrofused giant HEK293-cells as a novel electrophysiological expression system. Biochem Biophys Res Commun. 348(2):673-81.

    2005

    Nagel, G., P. Barbry, H. Chabot, E. Brochiero, K. Hartung and R. Grygorczyk. (2005) CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes. J Physiol (Lond) 564: 671-682.

    Nagel, G., T. Szellas, S. Kateriya, N. Adeishvili, P. Hegemann, E. Bamberg. Channelrhodopsins: directly light-gated cation channels. Biochemical Society Transactions (2005) 33(4): 863-866.

    Boyden, E.S., F. Zhang, E. Bamberg, G. Nagel, K. Deisseroth (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience 8(9):1263-8.

    Nagel, G., M. Brauner, J.F. Liewald, N. Adeishvili, E. Bamberg, A. Gottschalk (2005) Light-activation of Channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Current Biology 15(24):2279-84.

    2004

    Bettina Himmel & Georg Nagel (2004) Protein kinase-independent activation of CFTR by phosphatidylinositol phosphates. EMBO reports 5, 85–90.

    Nagel, G. (2004) CFTR, investigated with the two-electrode voltage-clamp technique: the importance of knowing the series resistance. Journal of Cystic Fibrosis 3: 109– 111.

    Kateriya S, Nagel G, Bamberg E, Hegemann P. (2004) "Vision" in single-celled algae. News Physiol Sci. 19:133-137.

    2003

    Nagel, G, T. Szellas, W. Huhn, S. Kateriya, N. Adeishvili, P. Berthold, D. Ollig, P. Hegemann, E. Bamberg. (2003) Channelrhodopsin-2, a directly Light-gated Cation-selective Membrane Channel. Proc Natl Acad Sci U.S.A. 100:13940-13945.

    Szellas, T. & G. Nagel (2003) Apparent affinity of CFTR for ATP is increased by continuous kinase activity.  FEBS Letters 535: 141-146. 

    Hippler-Mreyen, Silke, Johann P. Klare, Ansgar A. Wegener, Ralf Seidel, Christian Herrmann, Georg Schmies, Georg Nagel, Ernst Bamberg, and M. Engelhard (2003) Probing the Sensory Rhodopsin II Binding Domain of its Cognate Transducer by Calorimetry and Electrophysiology. J. Mol. Biol. 330, 1203–1213.

    Volk, C., V. Gorboulev, T. Budiman, G. Nagel, H. Koepsell. (2003) Different Affinities of Inhibitors to the Outwardly and Inwardly Directed Substrate Binding Site of Organic Cation Transporter 2. Molecular Pharmacology 64:1037-1047.

    2002

    Nagel G., D. Ollig, M. Fuhrmann, S. Kateriya, A.M. Musti, E. Bamberg, P. Hegemann (2002). Channelrhodopsin-1: a light-gated proton channel in green algae. Science 296: 2395-2398.

    Powe A, Zhou Z, Hwang T-C, Nagel G (2002). Quantitative Analysis of ATP-Dependent Gating of CFTR. Methods in Molecular Medicine 70:67-98.

    Haase A, Kappl M, Nagel G, Wood PG, Hartung K. (2002) The Ca/Ca Exchange Mode of the Na/Ca Exchanger Investigated by Photolytic Ca2+ Concentration Jumps.  Ann N Y Acad Sci. 976:113-116.

    Kontakt
    Universität Würzburg
    Lehrstuhl für Molekulare Pflanzenphysiologie und Biophysik - Botanik I
    Julius-von-Sachs-Platz 2
    97082 Würzburg

    Tel. +49 931 31-86101
    Fax. +49 931 31-86857

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