English
Lehrstuhl für Botanik I - Pflanzenphysiologie und Biophysik

Publikationen Prof. Thomas Müller

[ 2017 ] [ 2016 ] [ 2015 ] [ 2014 ] [ 2013 ] [ 2012 ] [ 2011 ] [ 2010 ] [ 2009 ] [ 2008 ] [ 2007 ] [ 2006 ] [ 2005 ] [ 2004 ] [ 2003 ] [ 2002 ] [ 2000 ] [ 1997 ] [ 1995 ] [ 1994 ] [ 1993 ]

2017 [ nach oben ]

  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U.D.A., Kübler, A.C., Sebald, W., Müller, T.D., Nickel, J. (2017) „Utilizing BMP-2 muteins for treatment of multiple myeloma“, PLOS ONE, 12(5), 1-18, available: https://doi.org/10.1371/journal.pone.0174884.
     
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J.C., Meinel, L., Fiebig, J.E., Mueller, T.D., Nickel, J. (2017) „Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds“, Biomacromolecules, 18(3), 695-708, available: https://www.ncbi.nlm.nih.gov/pubmed/28211679.
     
  • Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., Müller, T.D., Piehler, J. (2017) „Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments“, Nat Commun, 8, 15976-15976, available: https://www.ncbi.nlm.nih.gov/pubmed/28706306.
     
  • Patino, L.C., Walton, K.L., Mueller, T.D., Johnson, K.E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R.B., Laissue, P., Harrison, C.A. (2017) „BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9“, J Clin Endocrinol Metab, 102(3), 1009-1019.
     

2016 [ nach oben ]

  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A.R., Ehrlich, M., Henis, Y.I., Muller, T., Knaus, P. (2016) „Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling“, Int J Biochem Cell Biol, 76, 51-63, available: https://www.ncbi.nlm.nih.gov/pubmed/27113717.
     
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., Hedrich, R. (2016) „Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, 9(3), 428-36, available: https://www.ncbi.nlm.nih.gov/pubmed/26455461.
     
  • Boschert, V., Frisch, C., Back, J.W., van Pee, K., Weidauer, S.E., Muth, E.M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., Mueller, T.D. (2016) „The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6“, Open Biol, 6(8), available: https://www.ncbi.nlm.nih.gov/pubmed/27558933.
     
  • Yadin, D., Knaus, P., Mueller, T.D. (2016) „Structural insights into BMP receptors: Specificity, activation and inhibition“, Cytokine Growth Factor Rev, 27, 13-34, available: https://www.ncbi.nlm.nih.gov/pubmed/26690041.
     
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T.D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K.A., Rennenberg, H., Shabala, S., Neher, E., Hedrich, R. (2016) „The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake“, Curr Biol, 26(3), 286-95, available: https://www.ncbi.nlm.nih.gov/pubmed/26804557.
     
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A.L., Bauerlein, C.A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K.J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T.D., Reddehase, M.J., Lutz, M.B., Mannel, D.N., Berberich-Siebelt, F., Wajant, H., Beilhack, A. (2016) „Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion“, J Exp Med, 213(9), 1881-900, available: https://www.ncbi.nlm.nih.gov/pubmed/27526711.
     
  • Vendelova, E., Camargo de Lima, J., Lorenzatto, K.R., Monteiro, K.M., Mueller, T., Veepaschit, J., Grimm, C., Brehm, K., Hrckova, G., Lutz, M.B., Ferreira, H.B., Nono, J.K. (2016) „Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions“, PLoS Negl Trop Dis, 10(10), e0005061, available: https://www.ncbi.nlm.nih.gov/pubmed/27736880.
     
  • Johnson, K.E., Makanji, Y., Temple-Smith, P., Kelly, E.K., Barton, P.A., Al-Musawi, S.L., Mueller, T.D., Walton, K.L., Harrison, C.A. (2016) „Biological activity and in vivo half-life of pro-activin A in male rats“, Mol Cell Endocrinol, 422, 84-92, available: http://www.ncbi.nlm.nih.gov/pubmed/26687063.
     
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M.G., Fiebig, J., Mueller, T.D., Meinel, L. (2016) „Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization“, Chembiochem, 17(22), 2123-2128, available: https://www.ncbi.nlm.nih.gov/pubmed/27595549.
     
  • Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinne, S., Froese, A., Nikolaev, V.O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., Ferlini, A. (2016) „POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking“, J Clin Invest, 126(1), 239-53, available: https://www.ncbi.nlm.nih.gov/pubmed/26642364.
     
  • Palamides, P., Jodeleit, H., Fohlinger, M., Beigel, F., Herbach, N., Mueller, T., Wolf, E., Siebeck, M., Gropp, R. (2016) „A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals“, Dis Model Mech, 9(9), 985-97, available: https://www.ncbi.nlm.nih.gov/pubmed/27491073.
     
  • Jaslan, D., Mueller, T.D., Becker, D., Schultz, J., Cuin, T.A., Marten, I., Dreyer, I., Schonknecht, G., Hedrich, R. (2016) „Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain“, Plant Biol (Stuttg), 18(5), 750-60, available: https://www.ncbi.nlm.nih.gov/pubmed/27270880.
     
  • Chintalapati, C., Keller, T., Mueller, T.D., Gorboulev, V., Schafer, N., Zilkowski, I., Veyhl-Wichmann, M., Geiger, D., Groll, J., Koepsell, H. (2016) „Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase“, Mol Pharmacol, 90(5), 508-521, available: https://www.ncbi.nlm.nih.gov/pubmed/27555600.
     
  • Deeken, R., Saupe, S., Klinkenberg, J., Riedel, M., Leide, J., Hedrich, R., Mueller, T.D. (2016) „The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls“, Plant Physiol, 172(3), 1911-1927, available: https://www.ncbi.nlm.nih.gov/pubmed/27688623.
     
  • Hinck, A.P., Mueller, T.D., Springer, T.A. (2016) „Structural Biology and Evolution of the TGF-beta Family“, Cold Spring Harb Perspect Biol, 8(12), available: https://www.ncbi.nlm.nih.gov/pubmed/27638177.
     

2015 [ nach oben ]

  • Mottershead, D.G., Sugimura, S., Al-Musawi, S.L., Li, J.J., Richani, D., White, M.A., Martin, G.A., Trotta, A.P., Ritter, L.J., Shi, J., Mueller, T.D., Harrison, C.A., Gilchrist, R.B. (2015) „Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality“, J Biol Chem, 290(39), 24007-20, available: http://www.ncbi.nlm.nih.gov/pubmed/26254468.
     
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., Hedrich, R. (2015) „Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, available: http://www.ncbi.nlm.nih.gov/pubmed/26455461.
     
  • Stange, K., Desir, J., Kakar, N., Mueller, T.D., Budde, B.S., Gordon, C.T., Horn, D., Seemann, P., Borck, G. (2015) „A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia“, Orphanet J Rare Dis, 10, 84, available: http://www.ncbi.nlm.nih.gov/pubmed/26105076.
     
  • Paletta, D., Fichtner, A.S., Hahn, A.M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T.D., Herrmann, T. (2015) „The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs“, Eur J Immunol, 45(7), 2122-33, available: http://www.ncbi.nlm.nih.gov/pubmed/25900449.
     
  • Mueller, T.D. (2015) „RGM co-receptors add complexity to BMP signaling“, Nat Struct Mol Biol, 22(6), 439-40, available: http://www.ncbi.nlm.nih.gov/pubmed/26036568.
     
  • Li, J.J., Sugimura, S., Mueller, T.D., White, M.A., Martin, G.A., Ritter, L.J., Liang, X.Y., Gilchrist, R.B., Mottershead, D.G. (2015) „Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes“, Mol Endocrinol, 29(1), 40-52, available: http://www.ncbi.nlm.nih.gov/pubmed/25394262.
     
  • Mueller, T.D. (2015) „Mechanisms of BMP-Receptor Interaction and Activation“, Vitam Horm, 99, 1-61, available: http://www.ncbi.nlm.nih.gov/pubmed/26279372.
     
  • Klammert, U., Mueller, T.D., Hellmann, T.V., Wuerzler, K.K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A.C., Sebald, W., Nickel, J. (2015) „GDF-5 can act as a context-dependent BMP-2 antagonist“, BMC Biol, 13, 77, available: http://www.ncbi.nlm.nih.gov/pubmed/26385096.
     
  • Boschert, V., Muth, E.M., Knappik, A., Frisch, C., Mueller, T.D. (2015) „Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097“, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388-92, available: http://www.ncbi.nlm.nih.gov/pubmed/25849496.
     

2014 [ nach oben ]

  • Tzvetkov, M.V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., Koepsell, H. (2014) „Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?“, Blood, 123(9), 1427-9, available: http://www.ncbi.nlm.nih.gov/pubmed/24578499.
     
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Hermanns, H.M., Schafer, C.M., Kottmair, M., Muller, T., Sebald, W. (2014) „IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities“, Bioconjugate chemistry, 25(1), 52-62, available: http://www.ncbi.nlm.nih.gov/pubmed/24341642.
     
  • Graul-Neumann, L.M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T.D., Doelken, S.C., Seemann, P. (2014) „Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe“, European journal of human genetics : EJHG, 22(6), 726-33, available: http://www.ncbi.nlm.nih.gov/pubmed/24129431.
     
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K.A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T.D., Geiger, D. (2014) „A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective“, Plant Cell, 26(6), 2554-2567, available: http://www.ncbi.nlm.nih.gov/pubmed/24938289.
     

2013 [ nach oben ]

  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Varga, R., Herbach, N., Wanke, R., Wollenberg, A., Mueller, T., Gropp, R., Wolf, E., Siebeck, M. (2013) „Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Disease models & mechanisms, 6(1), 125-34, available: http://www.ncbi.nlm.nih.gov/pubmed/22822046.
     
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., Gropp, R. (2013) „Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Clinical and experimental immunology, 172(2), 349-62, available: http://www.ncbi.nlm.nih.gov/pubmed/23574330.
     
  • Zadeh-Khorasani, M., Nolte, T., Mueller, T.D., Pechlivanis, M., Rueff, F., Wollenberg, A., Fricker, G., Wolf, E., Siebeck, M., Gropp, R. (2013) „NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways“, Journal of translational medicine, 11, 4, available: http://www.ncbi.nlm.nih.gov/pubmed/23294516.
     
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E.M., Ten Dijke, P., Mueller, T.D. (2013) „Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition“, PLoS One, 8(11), e81710, available: http://www.ncbi.nlm.nih.gov/pubmed/24312339.
     
  • van Dinther, M., Zhang, J., Weidauer, S.E., Boschert, V., Muth, E.M., Knappik, A., de Gorter, D.J., van Kasteren, P.B., Frisch, C., Mueller, T.D., Ten Dijke, P. (2013) „Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling“, PLoS One, 8(4), e62295, available: http://www.ncbi.nlm.nih.gov/pubmed/23638027.
     
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R.P., Rapp, U.R., Rudel, T., Baljuls, A. (2013) „Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase“, The Journal of biological chemistry, 288(49), 35237-52, available: http://www.ncbi.nlm.nih.gov/pubmed/24158441.
     
  • Whitman, M., Rosen, V., Brivanlou, A.H., Groppe, J.C., Sebald, W., Mueller, T. (2013) „Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3“, Nature medicine, 19(7), 809-10, available: http://www.ncbi.nlm.nih.gov/pubmed/23836213.
     
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T.V., Mueller, T.D., Nickel, J., Eichler, J., Muller, Y.A. (2013) „Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3)“, PLoS One, 8(6), e67214, available: http://www.ncbi.nlm.nih.gov/pubmed/23826237.
     
  • Fiebig, J.E., Weidauer, S.E., Qiu, L.Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.L., Oschkinat, H., Sebald, W., Mueller, T.D. (2013) „The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed“, Molecules, 18(10), 11658-82, available: http://www.ncbi.nlm.nih.gov/pubmed/24071977.
     
  • Laisney, J.A., Mueller, T.D., Schartl, M., Meierjohann, S. (2013) „Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops“, Oncogene, 32(19), 2403-11, available: http://www.ncbi.nlm.nih.gov/pubmed/22751127.
     
  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K.A., Neher, E., Hedrich, R. (2013) „The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap's Prey Digestion“, Current biology : CB, 23(17), 1649-57, available: http://www.ncbi.nlm.nih.gov/pubmed/23954430.
     
  • Hannema, S.E., van Duyvenvoorde, H.A., Premsler, T., Yang, R.B., Mueller, T.D., Gassner, B., Oberwinkler, H., Roelfsema, F., Santen, G.W., Prickett, T., Kant, S.G., Verkerk, A.J., Uitterlinden, A.G., Espiner, E., Ruivenkamp, C.A., Oostdijk, W., Pereira, A.M., Losekoot, M., Kuhn, M., Wit, J.M. (2013) „An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities“, The Journal of clinical endocrinology and metabolism, 98(12), E1988-98, available: http://www.ncbi.nlm.nih.gov/pubmed/24057292.
     
  • Mottershead, D.G., Harrison, C.A., Mueller, T.D., Stanton, P.G., Gilchrist, R.B., McNatty, K.P. (2013) „Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization“, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available: http://www.ncbi.nlm.nih.gov/pubmed/23650403.
     

2012 [ nach oben ]

  • Mueller, T.D., Nickel, J. (2012) „Promiscuity and specificity in BMP receptor activation“, FEBS letters, 586(14), 1846-59, available: http://www.ncbi.nlm.nih.gov/pubmed/22710174.
     
  • Back, J.W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T.D., Knappik, A., Timmerman, P. (2012) „Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin“, Protein Eng Des Sel, 25(5), 251-9, available: http://www.ncbi.nlm.nih.gov/pubmed/22454505.
     
  • Hellmann, T.V., Nickel, J., Mueller, T.D. (2012) „Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation“, in Cooper, D. und Chen, J.-M., Hrsg., Gene Mutation, InTech: Rijeka, Croatia.
     
  • Schwaerzer, G.K., Hiepen, C., Schrewe, H., Nickel, J., Ploeger, F., Sebald, W., Mueller, T., Knaus, P. (2012) „New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance“, J Bone Miner Res, 27(2), 429-442, available: http://www.ncbi.nlm.nih.gov/pubmed/21976273.
     
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T.D., Sebald, W. (2012) „Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol“, Bioconjugate chemistry, 23(7), 1396-405, available: http://www.ncbi.nlm.nih.gov/pubmed/22681442.
     
  • Froese, A., Breher, S.S., Waldeyer, C., Schindler, R.F., Nikolaev, V.O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S.K., Laakmann, S., Muller, T.D., Neumann, J., Stieber, J., Ludwig, A., Maier, S.K., Decher, N., Arnold, H.H., Kirchhof, P., Fabritz, L., Brand, T. (2012) „Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice“, J Clin Invest, 122(3), 1119-30, available: http://www.ncbi.nlm.nih.gov/pubmed/22354168.
     
  • Urusova, D.V., Isupov, M.N., Antonyuk, S., Kachalova, G.S., Obmolova, G., Vagin, A.A., Lebedev, A.A., Burenkov, G.P., Dauter, Z., Bartunik, H.D., Lamzin, V.S., Melik-Adamyan, W.R., Mueller, T.D., Schnackerz, K.D. (2012) „Crystal structure of D-serine dehydratase from Escherichia coli“, Biochim Biophys Acta, 1824(3), 422-32, available: http://www.ncbi.nlm.nih.gov/pubmed/22197591.
     
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T.D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., Becker, D. (2012) „Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs)“, Molecular Plant, 6(4), 1274-1289, available: http://www.ncbi.nlm.nih.gov/pubmed/23253603.
     
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T.D., Koepsell, H. (2012) „A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1“, J Biol Chem, 287(37), 31561-73, available: http://www.ncbi.nlm.nih.gov/pubmed/22810231.
     

2011 [ nach oben ]

  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., Mueller, T.D. (2011) „Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha“, Structure, 19(12), 1864-75, available: http://www.ncbi.nlm.nih.gov/pubmed/22153509.
     
  • Nickel, J., Kotzsch, A., Sebald, W., Mueller, T.D. (2011) „Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)“, Acta Cryst F, 67(Pt 5), 551-5, available: http://www.ncbi.nlm.nih.gov/pubmed/21543859.
     
  • Billington, C.J., Fiebig, J.E., Forsman, C.L., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O'Connor, M.B., Mueller, T.D., Petryk, A. (2011) „Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development“, Front Physiol, 2, 59, available: http://www.ncbi.nlm.nih.gov/pubmed/21941513.
     
  • Seher, A., Nickel, J., Mueller, T.D., Kneitz, S., Gebhardt, S., ter Vehn, T.M., Schlunck, G., Sebald, W. (2011) „Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro“, Molecular Vision, 17, 53-62, available: http://www.ncbi.nlm.nih.gov/pubmed/21245951.
     
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., Rapp, U.R. (2011) „Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase“, J Biol Chem, 286(18), 16491-503, available: http://www.ncbi.nlm.nih.gov/pubmed/21454547.
     
  • Dadacz-Narloch, B., Beyhl, D., Larisch, C., Lopez-Sanjurjo, E.J., Reski, R., Kuchitsu, K., Muller, T.D., Becker, D., Schonknecht, G., Hedrich, R. (2011) „A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels“, Plant Cell, 23(7), 2696-707, available: http://www.ncbi.nlm.nih.gov/pubmed/21764990.
     

2010 [ nach oben ]

  • Sebald, W., Nickel, J., Zhang, J.L., Mueller, T.D. (2010) „Molecular basis of cytokine signalling--theme and variations“, FEBS J, 277(1), 106-18, available: http://www.ncbi.nlm.nih.gov/pubmed/19951357.
     
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J.P., Van Hul, W., Papapoulos, S. (2010) „First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function“, Hum Mutat, 31(7), E1526-43, available: http://www.ncbi.nlm.nih.gov/pubmed/20583295.
     
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S.E., de Gorter, D.J., van Bezooijen, R.L., Hatsell, S., Economides, A.N., Mueller, T.D., Lowik, C.W., ten Dijke, P. (2010) „Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways“, J Biol Chem, 285(53), 41614-26, available: http://www.ncbi.nlm.nih.gov/pubmed/20952383.
     
  • Harth, S., Kotzsch, A., Hu, J., Sebald, W., Mueller, T.D. (2010) „A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity“, PLoS One, 5(9), available: http://www.ncbi.nlm.nih.gov/pubmed/20927405.
     
  • Marcel, D., Muller, T., Hedrich, R., Geiger, D. (2010) „K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs“, FEBS Lett, 584(11), 2433-9, available: http://www.ncbi.nlm.nih.gov/pubmed/20412800.
     
  • Harth, S., Kotzsch, A., Sebald, W., Mueller, T.D. (2010) „Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964-8, available: http://www.ncbi.nlm.nih.gov/pubmed/20693682.
     

2009 [ nach oben ]

  • Heinecke, K., Seher, A., Schmitz, W., Mueller, T.D., Sebald, W., Nickel, J. (2009) „Receptor oligomerization and beyond: a case study in bone morphogenetic proteins“, BMC Biol, 7, 59, available: http://www.ncbi.nlm.nih.gov/pubmed/19735544.
     
  • Kotzsch, A., Nickel, J., Seher, A., Sebald, W., Muller, T.D. (2009) „Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity“, EMBO J, 28(7), 937-47, available: http://www.ncbi.nlm.nih.gov/pubmed/19229295.
     
  • Kotzsch, A., Nickel, J., Sebald, W., Mueller, T.D. (2009) „Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779-83, available: http://www.ncbi.nlm.nih.gov/pubmed/19652338.
     
  • Heupel, W.M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., Waschke, J. (2009) „Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus“, J Biol Chem, 284(13), 8589-95, available: http://www.ncbi.nlm.nih.gov/pubmed/19164289.
     
  • Volk, C., Gorboulev, V., Kotzsch, A., Muller, T.D., Koepsell, H. (2009) „Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone“, Mol Pharmacol, 76(2), 275-89, available: http://www.ncbi.nlm.nih.gov/pubmed/19435783.
     
  • Spindler, V., Heupel, W.M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Muller, T., Drenckhahn, D., Waschke, J. (2009) „Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus“, J Biol Chem, 284(44), 30556-64, available: http://www.ncbi.nlm.nih.gov/pubmed/19717567.
     
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T.D., Srinivasan, A., Hubner, S., Koepsell, H. (2009) „Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location“, Traffic, 10(11), 1599-618, available: http://www.ncbi.nlm.nih.gov/pubmed/19765263.
     
  • Nickel, J., Sebald, W., Groppe, J.C., Mueller, T.D. (2009) „Intricacies of BMP receptor assembly“, Cytokine Growth Factor Rev, 20(5-6), 367-77, available: http://www.ncbi.nlm.nih.gov/pubmed/19926516.
     
  • Schmitt, B.M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., Koepsell, H. (2009) „Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine“, Am J Physiol Renal Physiol, 296(4), F709-22, available: http://www.ncbi.nlm.nih.gov/pubmed/19211691.
     
  • Heupel, W.M., Efthymiadis, A., Schlegel, N., Muller, T., Baumer, Y., Baumgartner, W., Drenckhahn, D., Waschke, J. (2009) „Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo“, J Cell Sci, 122(Pt 10), 1616-25, available: http://www.ncbi.nlm.nih.gov/pubmed/19420236.
     
  • Weidauer, S.E., Schmieder, P., Beerbaum, M., Schmitz, W., Oschkinat, H., Mueller, T.D. (2009) „NMR structure of the Wnt modulator protein Sclerostin“, Biochem Biophys Res Commun, 380(1), 160-5, available: http://www.ncbi.nlm.nih.gov/pubmed/19166819.
     

2008 [ nach oben ]

  • Saremba, S., Nickel, J., Seher, A., Kotzsch, A., Sebald, W., Mueller, T.D. (2008) „Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand“, FEBS J, 275(1), 172-83, available: http://www.ncbi.nlm.nih.gov/pubmed/18070108.
     
  • Klages, J., Kotzsch, A., Coles, M., Sebald, W., Nickel, J., Muller, T., Kessler, H. (2008) „The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding“, Biochemistry, 47(46), 11930-9, available: http://www.ncbi.nlm.nih.gov/pubmed/18937504.
     
  • Qiu, L.Y., Zhang, J.L., Kotzsch, A., Sebald, W., Mueller, T.D. (2008) „Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307-12, available: http://www.ncbi.nlm.nih.gov/pubmed/18391434.
     
  • Kotzsch, A., Nickel, J., Seher, A., Heinecke, K., van Geersdaele, L., Herrmann, T., Sebald, W., Mueller, T.D. (2008) „Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome“, J Biol Chem, 283(9), 5876-87, available: http://www.ncbi.nlm.nih.gov/pubmed/18160401.
     
  • Baljuls, A., Schmitz, W., Mueller, T., Zahedi, R.P., Sickmann, A., Hekman, M., Rapp, U.R. (2008) „Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites“, J Biol Chem, 283(40), 27239-54, available: http://www.ncbi.nlm.nih.gov/pubmed/18662992.
     
  • Dunkel, M., Latz, A., Schumacher, K., Muller, T., Becker, D., Hedrich, R. (2008) „Targeting of vacuolar membrane localized members of the TPK channel family“, Mol Plant, 1(6), 938-49, available: http://www.ncbi.nlm.nih.gov/pubmed/19825594.
     
  • Gorbunov, D., Gorboulev, V., Shatskaya, N., Mueller, T., Bamberg, E., Friedrich, T., Koepsell, H. (2008) „High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices“, Mol Pharmacol, 73(1), 50-61, available: http://www.ncbi.nlm.nih.gov/pubmed/17940192.
     
  • Zhang, J.L., Qiu, L.Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., Mueller, T.D. (2008) „Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding“, Dev Cell, 14(5), 739-50, available: http://www.ncbi.nlm.nih.gov/pubmed/18477456.
     
  • Hartmann, M., Skryabin, B.V., Muller, T., Gazinski, A., Schroter, J., Gassner, B., Nikolaev, V.O., Bunemann, M., Kuhn, M. (2008) „Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling“, J Biol Chem, 283(42), 28313-20, available: http://www.ncbi.nlm.nih.gov/pubmed/18713751.
     

2007 [ nach oben ]

  • Mueller, T., Sebald, W. (2007) „Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren“, BIOspektrum, 3, 236-239.
     
  • Baljuls, A., Mueller, T., Drexler, H.C., Hekman, M., Rapp, U.R. (2007) „Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates“, J Biol Chem, 282(36), 26575-90, available: http://www.ncbi.nlm.nih.gov/pubmed/17613527.
     
  • Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., Mueller, T.D. (2007) „A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor“, BMC Struct Biol, 7, 6, available: http://www.ncbi.nlm.nih.gov/pubmed/17295905.
     
  • Sebald, W., Nickel, J., Seher, A., Mueller, T.D. (2007) „Bone morphogenetic proteins“, in Baeuerlein, E., Epple, M., Behrens, P. und Pompe, W., Hrsg., Handbook Of Biomineralization, Wiley-VCH Verlag GmbH Co. KGaA: Weinheim, 19-34.
     
  • Knackmuss, S., Krause, S., Engel, K., Reusch, U., Virchow, J.C., Mueller, T., Kraich, M., Little, M., Luttmann, W., Friedrich, K. (2007) „Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain“, Biol Chem, 388(3), 325-30, available: http://www.ncbi.nlm.nih.gov/pubmed/17338640.
     
  • Voss, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T.D., Felbor, U. (2007) „CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations“, Neurogenetics, 8(4), 249-56, available: http://www.ncbi.nlm.nih.gov/pubmed/17657516.
     
  • Latz, A., Becker, D., Hekman, M., Muller, T., Beyhl, D., Marten, I., Eing, C., Fischer, A., Dunkel, M., Bertl, A., Rapp, U.R., Hedrich, R. (2007) „TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins“, Plant J, 52(3), 449-59, available: http://www.ncbi.nlm.nih.gov/pubmed/17764516.
     

2006 [ nach oben ]

  • Meierjohann, S., Mueller, T., Schartl, M., Buehner, M. (2006) „A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk“, Zebrafish, 3(3), 359-69, available: http://www.ncbi.nlm.nih.gov/pubmed/18377216.
     
  • Kraich, M., Klein, M., Patino, E., Harrer, H., Nickel, J., Sebald, W., Mueller, T.D. (2006) „A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor“, BMC Biol, 4, 13, available: http://www.ncbi.nlm.nih.gov/pubmed/16640778.
     

2005 [ nach oben ]

  • Stahl, S., Gaetzner, S., Mueller, T.D., Felbor, U. (2005) „Endostatin phenylalanines 31 and 34 define a receptor binding site“, Genes Cells, 10(9), 929-39, available: http://www.ncbi.nlm.nih.gov/pubmed/16115201.
     
  • Popp, C., Gorboulev, V., Muller, T.D., Gorbunov, D., Shatskaya, N., Koepsell, H. (2005) „Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease“, Mol Pharmacol, 67(5), 1600-11, available: http://www.ncbi.nlm.nih.gov/pubmed/15662044.
     
  • Nickel, J., Kotzsch, A., Sebald, W., Mueller, T.D. (2005) „A single residue of GDF-5 defines binding specificity to BMP receptor IB“, J Mol Biol, 349(5), 933-47, available: http://www.ncbi.nlm.nih.gov/pubmed/15890363.
     
  • Mueller, T.D., Gottermeier, M., Sebald, W., Nickel, J. (2005) „Crystallization and preliminary X-ray diffraction analysis of human growth and differentiation factor 5 (GDF-5)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 61(Pt 1), 134-6, available: http://www.ncbi.nlm.nih.gov/pubmed/16508114.
     

2004 [ nach oben ]

  • Keller, S., Nickel, J., Zhang, J.L., Sebald, W., Mueller, T.D. (2004) „Molecular recognition of BMP-2 and BMP receptor IA“, Nat Struct Mol Biol, 11(5), 481-8, available: http://www.ncbi.nlm.nih.gov/pubmed/15064755.
     
  • Mueller, T.D., Kamionka, M., Feigon, J. (2004) „Specificity of the interaction between ubiquitin-associated domains and ubiquitin“, J Biol Chem, 279(12), 11926-36, available: http://www.ncbi.nlm.nih.gov/pubmed/14707125.
     
  • Sebald, W., Nickel, J., Zhang, J.L., Mueller, T.D. (2004) „Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction“, Biol Chem, 385(8), 697-710, available: http://www.ncbi.nlm.nih.gov/pubmed/15449706.
     
  • Johansson, C., Finger, L.D., Trantirek, L., Mueller, T.D., Kim, S., Laird-Offringa, I.A., Feigon, J. (2004) „Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target“, J Mol Biol, 337(4), 799-816, available: http://www.ncbi.nlm.nih.gov/pubmed/15033352.
     

2003 [ nach oben ]

  • Sebald, W., Mueller, T.D. (2003) „The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly“, Trends Biochem Sci, 28(10), 518-21, available: http://www.ncbi.nlm.nih.gov/pubmed/14559178.
     
  • Mueller, T.D., Feigon, J. (2003) „Structural determinants for the binding of ubiquitin-like domains to the proteasome“, EMBO J, 22(18), 4634-45, available: http://www.ncbi.nlm.nih.gov/pubmed/12970176.
     

2002 [ nach oben ]

  • Mueller, T.D., Zhang, J.L., Sebald, W., Duschl, A. (2002) „Structure, binding, and antagonists in the IL-4/IL-13 receptor system“, Biochim Biophys Acta, 1592(3), 237-50, available: http://www.ncbi.nlm.nih.gov/pubmed/12421669.
     
  • Mueller, T.D., Feigon, J. (2002) „Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions“, J Mol Biol, 319(5), 1243-55, available: http://www.ncbi.nlm.nih.gov/pubmed/12079361.
     

2000 [ nach oben ]

  • Withers-Ward, E.S., Mueller, T.D., Chen, I.S., Feigon, J. (2000) „Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr“, Biochemistry, 39(46), 14103-12, available: http://www.ncbi.nlm.nih.gov/pubmed/11087358.
     

1997 [ nach oben ]

  • Shaw, G.L., Muller, T., Campbell, I.D., Mott, H.R., Oschkinat, H., Mitschang, L. (1997) „Constant-time HQQC experiment for protein NMR spectroscopy“, Journal of Magnetic Resonance, 124(2), 479-483, available: /brokenurl#://WOS:A1997WP82100020.
     

1995 [ nach oben ]

  • Duschl, A., Muller, T., Sebald, W. (1995) „Antagonistic mutant proteins of interleukin-4“, Behring Inst Mitt, (96), 87-94, available: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.
     
  • Muller, T., Oehlenschlager, F., Buehner, M. (1995) „Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models“, Journal of Molecular Biology, 247(2), 360-372, available: /brokenurl#://WOS:A1995QP61000017.
     

1994 [ nach oben ]

  • Oschkinat, H., Muller, T., Dieckmann, T. (1994) „Protein-Structure Determination with 3-Dimensional and 4-Dimensional Nmr-Spectroscopy“, Angewandte Chemie-International Edition in English, 33(3), 277-293, available: /brokenurl#://WOS:A1994MX73200002.
     
  • Demchuk, E., Mueller, T., Oschkinat, H., Sebald, W., Wade, R.C. (1994) „Receptor-Binding Properties of 4-Helix-Bundle Growth-Factors Deduced from Electrostatic Analysis“, Protein Science, 3(6), 920-935, available: /brokenurl#://WOS:A1994NN55000009.
     
  • Muller, T., Dieckmann, T., Sebald, W., Oschkinat, H. (1994) „Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy“, Journal of Molecular Biology, 237(4), 423-436, available: /brokenurl#://WOS:A1994NF55400007.
     
  • Muller, T., Sebald, W., Oschkinat, H. (1994) „Antagonist Design through Forced Electrostatic Mismatch“, Nature Structural Biology, 1(10), 674-676, available: /brokenurl#://WOS:A1994QN60600006.
     

1993 [ nach oben ]

  • Kruse, N., Shen, B.J., Arnold, S., Tony, H.P., Muller, T., Sebald, W. (1993) „2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation“, Embo Journal, 12(13), 5121-5129, available: /brokenurl#://WOS:A1993MM12000024.
     
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