English
Lehrstuhl für Botanik I - Pflanzenphysiologie und Biophysik

Publikationen Prof. Thomas Müller

[2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2000] [1997] [1995] [1994] [1993]

2017 [ nach oben ]

  • Patino, L.C., Walton, K.L., Mueller, T.D., Johnson, K.E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R.B., Laissue, P., Harrison, C.A. (2017) „BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9“, J Clin Endocrinol Metab, 102(3), 1009-1019.
     
  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U.D.A., Kübler, A.C., Sebald, W., Müller, T.D., Nickel, J. (2017) „Utilizing BMP-2 muteins for treatment of multiple myeloma“, PLOS ONE, 12(5), 1-18, available: https://doi.org/10.1371/journal.pone.0174884.
     
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J.C., Meinel, L., Fiebig, J.E., Mueller, T.D., Nickel, J. (2017) „Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds“, Biomacromolecules, 18(3), 695-708, available: https://www.ncbi.nlm.nih.gov/pubmed/28211679.
     

2016 [ nach oben ]

  • Boschert, V., Frisch, C., Back, J.W., van Pee, K., Weidauer, S.E., Muth, E.M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., Mueller, T.D. (2016) „The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6“, Open Biol, 6(8), available: https://www.ncbi.nlm.nih.gov/pubmed/27558933.
     
  • Yadin, D., Knaus, P., Mueller, T.D. (2016) „Structural insights into BMP receptors: Specificity, activation and inhibition“, Cytokine Growth Factor Rev, 27, 13-34, available: https://www.ncbi.nlm.nih.gov/pubmed/26690041.
     
  • Jaslan, D., Mueller, T.D., Becker, D., Schultz, J., Cuin, T.A., Marten, I., Dreyer, I., Schonknecht, G., Hedrich, R. (2016) „Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain“, Plant Biol (Stuttg), 18(5), 750-60, available: https://www.ncbi.nlm.nih.gov/pubmed/27270880.
     
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T.D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K.A., Rennenberg, H., Shabala, S., Neher, E., Hedrich, R. (2016) „The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake“, Curr Biol, 26(3), 286-95, available: https://www.ncbi.nlm.nih.gov/pubmed/26804557.
     
  • Deeken, R., Saupe, S., Klinkenberg, J., Riedel, M., Leide, J., Hedrich, R., Mueller, T.D. (2016) „The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls“, Plant Physiol, 172(3), 1911-1927, available: https://www.ncbi.nlm.nih.gov/pubmed/27688623.
     
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., Hedrich, R. (2016) „Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, 9(3), 428-36, available: https://www.ncbi.nlm.nih.gov/pubmed/26455461.
     
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A.L., Bauerlein, C.A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K.J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T.D., Reddehase, M.J., Lutz, M.B., Mannel, D.N., Berberich-Siebelt, F., Wajant, H., Beilhack, A. (2016) „Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion“, J Exp Med, 213(9), 1881-900, available: https://www.ncbi.nlm.nih.gov/pubmed/27526711.
     
  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A.R., Ehrlich, M., Henis, Y.I., Muller, T., Knaus, P. (2016) „Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling“, Int J Biochem Cell Biol, 76, 51-63, available: https://www.ncbi.nlm.nih.gov/pubmed/27113717.
     
  • Johnson, K.E., Makanji, Y., Temple-Smith, P., Kelly, E.K., Barton, P.A., Al-Musawi, S.L., Mueller, T.D., Walton, K.L., Harrison, C.A. (2016) „Biological activity and in vivo half-life of pro-activin A in male rats“, Mol Cell Endocrinol, 422, 84-92, available: http://www.ncbi.nlm.nih.gov/pubmed/26687063.
     
  • Vendelova, E., Camargo de Lima, J., Lorenzatto, K.R., Monteiro, K.M., Mueller, T., Veepaschit, J., Grimm, C., Brehm, K., Hrckova, G., Lutz, M.B., Ferreira, H.B., Nono, J.K. (2016) „Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions“, PLoS Negl Trop Dis, 10(10), e0005061, available: https://www.ncbi.nlm.nih.gov/pubmed/27736880.
     
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M.G., Fiebig, J., Mueller, T.D., Meinel, L. (2016) „Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization“, Chembiochem, 17(22), 2123-2128, available: https://www.ncbi.nlm.nih.gov/pubmed/27595549.
     
  • Palamides, P., Jodeleit, H., Fohlinger, M., Beigel, F., Herbach, N., Mueller, T., Wolf, E., Siebeck, M., Gropp, R. (2016) „A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals“, Dis Model Mech, 9(9), 985-97, available: https://www.ncbi.nlm.nih.gov/pubmed/27491073.
     
  • Chintalapati, C., Keller, T., Mueller, T.D., Gorboulev, V., Schafer, N., Zilkowski, I., Veyhl-Wichmann, M., Geiger, D., Groll, J., Koepsell, H. (2016) „Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase“, Mol Pharmacol, 90(5), 508-521, available: https://www.ncbi.nlm.nih.gov/pubmed/27555600.
     
  • Hinck, A.P., Mueller, T.D., Springer, T.A. (2016) „Structural Biology and Evolution of the TGF-beta Family“, Cold Spring Harb Perspect Biol, 8(12), available: https://www.ncbi.nlm.nih.gov/pubmed/27638177.
     
  • Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinne, S., Froese, A., Nikolaev, V.O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., Ferlini, A. (2016) „POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking“, J Clin Invest, 126(1), 239-53, available: https://www.ncbi.nlm.nih.gov/pubmed/26642364.
     

2015 [ nach oben ]

  • Klammert, U., Mueller, T.D., Hellmann, T.V., Wuerzler, K.K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A.C., Sebald, W., Nickel, J. (2015) „GDF-5 can act as a context-dependent BMP-2 antagonist“, BMC Biol, 13, 77, available: http://www.ncbi.nlm.nih.gov/pubmed/26385096.
     
  • Boschert, V., Muth, E.M., Knappik, A., Frisch, C., Mueller, T.D. (2015) „Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097“, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388-92, available: http://www.ncbi.nlm.nih.gov/pubmed/25849496.
     
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., Hedrich, R. (2015) „Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability“, Mol Plant, available: http://www.ncbi.nlm.nih.gov/pubmed/26455461.
     
  • Paletta, D., Fichtner, A.S., Hahn, A.M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T.D., Herrmann, T. (2015) „The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs“, Eur J Immunol, 45(7), 2122-33, available: http://www.ncbi.nlm.nih.gov/pubmed/25900449.
     
  • Mottershead, D.G., Sugimura, S., Al-Musawi, S.L., Li, J.J., Richani, D., White, M.A., Martin, G.A., Trotta, A.P., Ritter, L.J., Shi, J., Mueller, T.D., Harrison, C.A., Gilchrist, R.B. (2015) „Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality“, J Biol Chem, 290(39), 24007-20, available: http://www.ncbi.nlm.nih.gov/pubmed/26254468.
     
  • Mueller, T.D. (2015) „Mechanisms of BMP-Receptor Interaction and Activation“, Vitam Horm, 99, 1-61, available: http://www.ncbi.nlm.nih.gov/pubmed/26279372.
     
  • Mueller, T.D. (2015) „RGM co-receptors add complexity to BMP signaling“, Nat Struct Mol Biol, 22(6), 439-40, available: http://www.ncbi.nlm.nih.gov/pubmed/26036568.
     
  • Stange, K., Desir, J., Kakar, N., Mueller, T.D., Budde, B.S., Gordon, C.T., Horn, D., Seemann, P., Borck, G. (2015) „A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia“, Orphanet J Rare Dis, 10, 84, available: http://www.ncbi.nlm.nih.gov/pubmed/26105076.
     
  • Li, J.J., Sugimura, S., Mueller, T.D., White, M.A., Martin, G.A., Ritter, L.J., Liang, X.Y., Gilchrist, R.B., Mottershead, D.G. (2015) „Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes“, Mol Endocrinol, 29(1), 40-52, available: http://www.ncbi.nlm.nih.gov/pubmed/25394262.
     

2014 [ nach oben ]

  • Graul-Neumann, L.M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T.D., Doelken, S.C., Seemann, P. (2014) „Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe“, European journal of human genetics : EJHG, 22(6), 726-33, available: http://www.ncbi.nlm.nih.gov/pubmed/24129431.
     
  • Tzvetkov, M.V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., Koepsell, H. (2014) „Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?“, Blood, 123(9), 1427-9, available: http://www.ncbi.nlm.nih.gov/pubmed/24578499.
     
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Hermanns, H.M., Schafer, C.M., Kottmair, M., Muller, T., Sebald, W. (2014) „IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities“, Bioconjugate chemistry, 25(1), 52-62, available: http://www.ncbi.nlm.nih.gov/pubmed/24341642.
     
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K.A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T.D., Geiger, D. (2014) „A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective“, Plant Cell, 26(6), 2554-2567, available: http://www.ncbi.nlm.nih.gov/pubmed/24938289.
     

2013 [ nach oben ]

  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K.A., Neher, E., Hedrich, R. (2013) „The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap's Prey Digestion“, Current biology : CB, 23(17), 1649-57, available: http://www.ncbi.nlm.nih.gov/pubmed/23954430.
     
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E.M., Ten Dijke, P., Mueller, T.D. (2013) „Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition“, PLoS One, 8(11), e81710, available: http://www.ncbi.nlm.nih.gov/pubmed/24312339.
     
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T.V., Mueller, T.D., Nickel, J., Eichler, J., Muller, Y.A. (2013) „Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3)“, PLoS One, 8(6), e67214, available: http://www.ncbi.nlm.nih.gov/pubmed/23826237.
     
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R.P., Rapp, U.R., Rudel, T., Baljuls, A. (2013) „Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase“, The Journal of biological chemistry, 288(49), 35237-52, available: http://www.ncbi.nlm.nih.gov/pubmed/24158441.
     
  • Fiebig, J.E., Weidauer, S.E., Qiu, L.Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.L., Oschkinat, H., Sebald, W., Mueller, T.D. (2013) „The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed“, Molecules, 18(10), 11658-82, available: http://www.ncbi.nlm.nih.gov/pubmed/24071977.
     
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., Gropp, R. (2013) „Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Clinical and experimental immunology, 172(2), 349-62, available: http://www.ncbi.nlm.nih.gov/pubmed/23574330.
     
  • Zadeh-Khorasani, M., Nolte, T., Mueller, T.D., Pechlivanis, M., Rueff, F., Wollenberg, A., Fricker, G., Wolf, E., Siebeck, M., Gropp, R. (2013) „NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways“, Journal of translational medicine, 11, 4, available: http://www.ncbi.nlm.nih.gov/pubmed/23294516.
     
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Varga, R., Herbach, N., Wanke, R., Wollenberg, A., Mueller, T., Gropp, R., Wolf, E., Siebeck, M. (2013) „Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells“, Disease models & mechanisms, 6(1), 125-34, available: http://www.ncbi.nlm.nih.gov/pubmed/22822046.
     
  • Laisney, J.A., Mueller, T.D., Schartl, M., Meierjohann, S. (2013) „Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops“, Oncogene, 32(19), 2403-11, available: http://www.ncbi.nlm.nih.gov/pubmed/22751127.
     
  • Hannema, S.E., van Duyvenvoorde, H.A., Premsler, T., Yang, R.B., Mueller, T.D., Gassner, B., Oberwinkler, H., Roelfsema, F., Santen, G.W., Prickett, T., Kant, S.G., Verkerk, A.J., Uitterlinden, A.G., Espiner, E., Ruivenkamp, C.A., Oostdijk, W., Pereira, A.M., Losekoot, M., Kuhn, M., Wit, J.M. (2013) „An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities“, The Journal of clinical endocrinology and metabolism, 98(12), E1988-98, available: http://www.ncbi.nlm.nih.gov/pubmed/24057292.
     
  • van Dinther, M., Zhang, J., Weidauer, S.E., Boschert, V., Muth, E.M., Knappik, A., de Gorter, D.J., van Kasteren, P.B., Frisch, C., Mueller, T.D., Ten Dijke, P. (2013) „Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling“, PLoS One, 8(4), e62295, available: http://www.ncbi.nlm.nih.gov/pubmed/23638027.
     
  • Whitman, M., Rosen, V., Brivanlou, A.H., Groppe, J.C., Sebald, W., Mueller, T. (2013) „Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3“, Nature medicine, 19(7), 809-10, available: http://www.ncbi.nlm.nih.gov/pubmed/23836213.
     
  • Mottershead, D.G., Harrison, C.A., Mueller, T.D., Stanton, P.G., Gilchrist, R.B., McNatty, K.P. (2013) „Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization“, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available: http://www.ncbi.nlm.nih.gov/pubmed/23650403.
     

2012 [ nach oben ]

  • Urusova, D.V., Isupov, M.N., Antonyuk, S., Kachalova, G.S., Obmolova, G., Vagin, A.A., Lebedev, A.A., Burenkov, G.P., Dauter, Z., Bartunik, H.D., Lamzin, V.S., Melik-Adamyan, W.R., Mueller, T.D., Schnackerz, K.D. (2012) „Crystal structure of D-serine dehydratase from Escherichia coli“, Biochim Biophys Acta, 1824(3), 422-32, available: http://www.ncbi.nlm.nih.gov/pubmed/22197591.
     
  • Schwaerzer, G.K., Hiepen, C., Schrewe, H., Nickel, J., Ploeger, F., Sebald, W., Mueller, T., Knaus, P. (2012) „New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance“, J Bone Miner Res, 27(2), 429-442, available: http://www.ncbi.nlm.nih.gov/pubmed/21976273.
     
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T.D., Sebald, W. (2012) „Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol“, Bioconjugate chemistry, 23(7), 1396-405, available: http://www.ncbi.nlm.nih.gov/pubmed/22681442.
     
  • Back, J.W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T.D., Knappik, A., Timmerman, P. (2012) „Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin“, Protein Eng Des Sel, 25(5), 251-9, available: http://www.ncbi.nlm.nih.gov/pubmed/22454505.
     
  • Mueller, T.D., Nickel, J. (2012) „Promiscuity and specificity in BMP receptor activation“, FEBS letters, 586(14), 1846-59, available: http://www.ncbi.nlm.nih.gov/pubmed/22710174.
     
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T.D., Koepsell, H. (2012) „A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1“, J Biol Chem, 287(37), 31561-73, available: http://www.ncbi.nlm.nih.gov/pubmed/22810231.
     
  • Hellmann, T.V., Nickel, J., Mueller, T.D. (2012) „Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation“, in Cooper, D. und Chen, J.-M., Hrsg., Gene Mutation, InTech: Rijeka, Croatia.
     
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T.D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., Becker, D. (2012) „Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs)“, Molecular Plant, 6(4), 1274-1289, available: http://www.ncbi.nlm.nih.gov/pubmed/23253603.
     
  • Froese, A., Breher, S.S., Waldeyer, C., Schindler, R.F., Nikolaev, V.O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S.K., Laakmann, S., Muller, T.D., Neumann, J., Stieber, J., Ludwig, A., Maier, S.K., Decher, N., Arnold, H.H., Kirchhof, P., Fabritz, L., Brand, T. (2012) „Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice“, J Clin Invest, 122(3), 1119-30, available: http://www.ncbi.nlm.nih.gov/pubmed/22354168.
     

2011 [ nach oben ]

  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., Mueller, T.D. (2011) „Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha“, Structure, 19(12), 1864-75, available: http://www.ncbi.nlm.nih.gov/pubmed/22153509.
     
  • Dadacz-Narloch, B., Beyhl, D., Larisch, C., Lopez-Sanjurjo, E.J., Reski, R., Kuchitsu, K., Muller, T.D., Becker, D., Schonknecht, G., Hedrich, R. (2011) „A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels“, Plant Cell, 23(7), 2696-707, available: http://www.ncbi.nlm.nih.gov/pubmed/21764990.
     
  • Nickel, J., Kotzsch, A., Sebald, W., Mueller, T.D. (2011) „Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)“, Acta Cryst F, 67(Pt 5), 551-5, available: http://www.ncbi.nlm.nih.gov/pubmed/21543859.
     
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., Rapp, U.R. (2011) „Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase“, J Biol Chem, 286(18), 16491-503, available: http://www.ncbi.nlm.nih.gov/pubmed/21454547.
     
  • Billington, C.J., Fiebig, J.E., Forsman, C.L., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O'Connor, M.B., Mueller, T.D., Petryk, A. (2011) „Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development“, Front Physiol, 2, 59, available: http://www.ncbi.nlm.nih.gov/pubmed/21941513.
     
  • Seher, A., Nickel, J., Mueller, T.D., Kneitz, S., Gebhardt, S., ter Vehn, T.M., Schlunck, G., Sebald, W. (2011) „Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro“, Molecular Vision, 17, 53-62, available: http://www.ncbi.nlm.nih.gov/pubmed/21245951.
     

2010 [ nach oben ]

  • Harth, S., Kotzsch, A., Hu, J., Sebald, W., Mueller, T.D. (2010) „A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity“, PLoS One, 5(9), available: http://www.ncbi.nlm.nih.gov/pubmed/20927405.
     
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S.E., de Gorter, D.J., van Bezooijen, R.L., Hatsell, S., Economides, A.N., Mueller, T.D., Lowik, C.W., ten Dijke, P. (2010) „Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways“, J Biol Chem, 285(53), 41614-26, available: http://www.ncbi.nlm.nih.gov/pubmed/20952383.
     
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J.P., Van Hul, W., Papapoulos, S. (2010) „First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function“, Hum Mutat, 31(7), E1526-43, available: http://www.ncbi.nlm.nih.gov/pubmed/20583295.
     
  • Marcel, D., Muller, T., Hedrich, R., Geiger, D. (2010) „K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs“, FEBS Lett, 584(11), 2433-9, available: http://www.ncbi.nlm.nih.gov/pubmed/20412800.
     
  • Sebald, W., Nickel, J., Zhang, J.L., Mueller, T.D. (2010) „Molecular basis of cytokine signalling--theme and variations“, FEBS J, 277(1), 106-18, available: http://www.ncbi.nlm.nih.gov/pubmed/19951357.
     
  • Harth, S., Kotzsch, A., Sebald, W., Mueller, T.D. (2010) „Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964-8, available: http://www.ncbi.nlm.nih.gov/pubmed/20693682.
     

2009 [ nach oben ]

  • Heupel, W.M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., Waschke, J. (2009) „Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus“, J Biol Chem, 284(13), 8589-95, available: http://www.ncbi.nlm.nih.gov/pubmed/19164289.
     
  • Spindler, V., Heupel, W.M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Muller, T., Drenckhahn, D., Waschke, J. (2009) „Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus“, J Biol Chem, 284(44), 30556-64, available: http://www.ncbi.nlm.nih.gov/pubmed/19717567.
     
  • Weidauer, S.E., Schmieder, P., Beerbaum, M., Schmitz, W., Oschkinat, H., Mueller, T.D. (2009) „NMR structure of the Wnt modulator protein Sclerostin“, Biochem Biophys Res Commun, 380(1), 160-5, available: http://www.ncbi.nlm.nih.gov/pubmed/19166819.
     
  • Kotzsch, A., Nickel, J., Sebald, W., Mueller, T.D. (2009) „Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779-83, available: http://www.ncbi.nlm.nih.gov/pubmed/19652338.
     
  • Kotzsch, A., Nickel, J., Seher, A., Sebald, W., Muller, T.D. (2009) „Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity“, EMBO J, 28(7), 937-47, available: http://www.ncbi.nlm.nih.gov/pubmed/19229295.
     
  • Schmitt, B.M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., Koepsell, H. (2009) „Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine“, Am J Physiol Renal Physiol, 296(4), F709-22, available: http://www.ncbi.nlm.nih.gov/pubmed/19211691.
     
  • Nickel, J., Sebald, W., Groppe, J.C., Mueller, T.D. (2009) „Intricacies of BMP receptor assembly“, Cytokine Growth Factor Rev, 20(5-6), 367-77, available: http://www.ncbi.nlm.nih.gov/pubmed/19926516.
     
  • Heupel, W.M., Efthymiadis, A., Schlegel, N., Muller, T., Baumer, Y., Baumgartner, W., Drenckhahn, D., Waschke, J. (2009) „Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo“, J Cell Sci, 122(Pt 10), 1616-25, available: http://www.ncbi.nlm.nih.gov/pubmed/19420236.
     
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T.D., Srinivasan, A., Hubner, S., Koepsell, H. (2009) „Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location“, Traffic, 10(11), 1599-618, available: http://www.ncbi.nlm.nih.gov/pubmed/19765263.
     
  • Heinecke, K., Seher, A., Schmitz, W., Mueller, T.D., Sebald, W., Nickel, J. (2009) „Receptor oligomerization and beyond: a case study in bone morphogenetic proteins“, BMC Biol, 7, 59, available: http://www.ncbi.nlm.nih.gov/pubmed/19735544.
     
  • Volk, C., Gorboulev, V., Kotzsch, A., Muller, T.D., Koepsell, H. (2009) „Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone“, Mol Pharmacol, 76(2), 275-89, available: http://www.ncbi.nlm.nih.gov/pubmed/19435783.
     

2008 [ nach oben ]

  • Dunkel, M., Latz, A., Schumacher, K., Muller, T., Becker, D., Hedrich, R. (2008) „Targeting of vacuolar membrane localized members of the TPK channel family“, Mol Plant, 1(6), 938-49, available: http://www.ncbi.nlm.nih.gov/pubmed/19825594.
     
  • Baljuls, A., Schmitz, W., Mueller, T., Zahedi, R.P., Sickmann, A., Hekman, M., Rapp, U.R. (2008) „Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites“, J Biol Chem, 283(40), 27239-54, available: http://www.ncbi.nlm.nih.gov/pubmed/18662992.
     
  • Qiu, L.Y., Zhang, J.L., Kotzsch, A., Sebald, W., Mueller, T.D. (2008) „Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307-12, available: http://www.ncbi.nlm.nih.gov/pubmed/18391434.
     
  • Saremba, S., Nickel, J., Seher, A., Kotzsch, A., Sebald, W., Mueller, T.D. (2008) „Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand“, FEBS J, 275(1), 172-83, available: http://www.ncbi.nlm.nih.gov/pubmed/18070108.
     
  • Zhang, J.L., Qiu, L.Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., Mueller, T.D. (2008) „Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding“, Dev Cell, 14(5), 739-50, available: http://www.ncbi.nlm.nih.gov/pubmed/18477456.
     
  • Kotzsch, A., Nickel, J., Seher, A., Heinecke, K., van Geersdaele, L., Herrmann, T., Sebald, W., Mueller, T.D. (2008) „Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome“, J Biol Chem, 283(9), 5876-87, available: http://www.ncbi.nlm.nih.gov/pubmed/18160401.
     
  • Gorbunov, D., Gorboulev, V., Shatskaya, N., Mueller, T., Bamberg, E., Friedrich, T., Koepsell, H. (2008) „High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices“, Mol Pharmacol, 73(1), 50-61, available: http://www.ncbi.nlm.nih.gov/pubmed/17940192.
     
  • Klages, J., Kotzsch, A., Coles, M., Sebald, W., Nickel, J., Muller, T., Kessler, H. (2008) „The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding“, Biochemistry, 47(46), 11930-9, available: http://www.ncbi.nlm.nih.gov/pubmed/18937504.
     
  • Hartmann, M., Skryabin, B.V., Muller, T., Gazinski, A., Schroter, J., Gassner, B., Nikolaev, V.O., Bunemann, M., Kuhn, M. (2008) „Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling“, J Biol Chem, 283(42), 28313-20, available: http://www.ncbi.nlm.nih.gov/pubmed/18713751.
     

2007 [ nach oben ]

  • Voss, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T.D., Felbor, U. (2007) „CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations“, Neurogenetics, 8(4), 249-56, available: http://www.ncbi.nlm.nih.gov/pubmed/17657516.
     
  • Latz, A., Becker, D., Hekman, M., Muller, T., Beyhl, D., Marten, I., Eing, C., Fischer, A., Dunkel, M., Bertl, A., Rapp, U.R., Hedrich, R. (2007) „TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins“, Plant J, 52(3), 449-59, available: http://www.ncbi.nlm.nih.gov/pubmed/17764516.
     
  • Baljuls, A., Mueller, T., Drexler, H.C., Hekman, M., Rapp, U.R. (2007) „Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates“, J Biol Chem, 282(36), 26575-90, available: http://www.ncbi.nlm.nih.gov/pubmed/17613527.
     
  • Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., Mueller, T.D. (2007) „A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor“, BMC Struct Biol, 7, 6, available: http://www.ncbi.nlm.nih.gov/pubmed/17295905.
     
  • Mueller, T., Sebald, W. (2007) „Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren“, BIOspektrum, 3, 236-239.
     
  • Sebald, W., Nickel, J., Seher, A., Mueller, T.D. (2007) „Bone morphogenetic proteins“, in Baeuerlein, E., Epple, M., Behrens, P. und Pompe, W., Hrsg., Handbook Of Biomineralization, Wiley-VCH Verlag GmbH Co. KGaA: Weinheim, 19-34.
     
  • Knackmuss, S., Krause, S., Engel, K., Reusch, U., Virchow, J.C., Mueller, T., Kraich, M., Little, M., Luttmann, W., Friedrich, K. (2007) „Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain“, Biol Chem, 388(3), 325-30, available: http://www.ncbi.nlm.nih.gov/pubmed/17338640.
     

2006 [ nach oben ]

  • Meierjohann, S., Mueller, T., Schartl, M., Buehner, M. (2006) „A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk“, Zebrafish, 3(3), 359-69, available: http://www.ncbi.nlm.nih.gov/pubmed/18377216.
     
  • Kraich, M., Klein, M., Patino, E., Harrer, H., Nickel, J., Sebald, W., Mueller, T.D. (2006) „A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor“, BMC Biol, 4, 13, available: http://www.ncbi.nlm.nih.gov/pubmed/16640778.
     

2005 [ nach oben ]

  • Nickel, J., Kotzsch, A., Sebald, W., Mueller, T.D. (2005) „A single residue of GDF-5 defines binding specificity to BMP receptor IB“, J Mol Biol, 349(5), 933-47, available: http://www.ncbi.nlm.nih.gov/pubmed/15890363.
     
  • Popp, C., Gorboulev, V., Muller, T.D., Gorbunov, D., Shatskaya, N., Koepsell, H. (2005) „Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease“, Mol Pharmacol, 67(5), 1600-11, available: http://www.ncbi.nlm.nih.gov/pubmed/15662044.
     
  • Mueller, T.D., Gottermeier, M., Sebald, W., Nickel, J. (2005) „Crystallization and preliminary X-ray diffraction analysis of human growth and differentiation factor 5 (GDF-5)“, Acta Crystallogr Sect F Struct Biol Cryst Commun, 61(Pt 1), 134-6, available: http://www.ncbi.nlm.nih.gov/pubmed/16508114.
     
  • Stahl, S., Gaetzner, S., Mueller, T.D., Felbor, U. (2005) „Endostatin phenylalanines 31 and 34 define a receptor binding site“, Genes Cells, 10(9), 929-39, available: http://www.ncbi.nlm.nih.gov/pubmed/16115201.
     

2004 [ nach oben ]

  • Sebald, W., Nickel, J., Zhang, J.L., Mueller, T.D. (2004) „Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction“, Biol Chem, 385(8), 697-710, available: http://www.ncbi.nlm.nih.gov/pubmed/15449706.
     
  • Keller, S., Nickel, J., Zhang, J.L., Sebald, W., Mueller, T.D. (2004) „Molecular recognition of BMP-2 and BMP receptor IA“, Nat Struct Mol Biol, 11(5), 481-8, available: http://www.ncbi.nlm.nih.gov/pubmed/15064755.
     
  • Johansson, C., Finger, L.D., Trantirek, L., Mueller, T.D., Kim, S., Laird-Offringa, I.A., Feigon, J. (2004) „Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target“, J Mol Biol, 337(4), 799-816, available: http://www.ncbi.nlm.nih.gov/pubmed/15033352.
     
  • Mueller, T.D., Kamionka, M., Feigon, J. (2004) „Specificity of the interaction between ubiquitin-associated domains and ubiquitin“, J Biol Chem, 279(12), 11926-36, available: http://www.ncbi.nlm.nih.gov/pubmed/14707125.
     

2003 [ nach oben ]

  • Sebald, W., Mueller, T.D. (2003) „The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly“, Trends Biochem Sci, 28(10), 518-21, available: http://www.ncbi.nlm.nih.gov/pubmed/14559178.
     
  • Mueller, T.D., Feigon, J. (2003) „Structural determinants for the binding of ubiquitin-like domains to the proteasome“, EMBO J, 22(18), 4634-45, available: http://www.ncbi.nlm.nih.gov/pubmed/12970176.
     

2002 [ nach oben ]

  • Mueller, T.D., Feigon, J. (2002) „Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions“, J Mol Biol, 319(5), 1243-55, available: http://www.ncbi.nlm.nih.gov/pubmed/12079361.
     
  • Mueller, T.D., Zhang, J.L., Sebald, W., Duschl, A. (2002) „Structure, binding, and antagonists in the IL-4/IL-13 receptor system“, Biochim Biophys Acta, 1592(3), 237-50, available: http://www.ncbi.nlm.nih.gov/pubmed/12421669.
     

2000 [ nach oben ]

  • Withers-Ward, E.S., Mueller, T.D., Chen, I.S., Feigon, J. (2000) „Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr“, Biochemistry, 39(46), 14103-12, available: http://www.ncbi.nlm.nih.gov/pubmed/11087358.
     

1997 [ nach oben ]

  • Shaw, G.L., Muller, T., Campbell, I.D., Mott, H.R., Oschkinat, H., Mitschang, L. (1997) „Constant-time HQQC experiment for protein NMR spectroscopy“, Journal of Magnetic Resonance, 124(2), 479-483, available: /brokenurl#://WOS:A1997WP82100020.
     

1995 [ nach oben ]

  • Muller, T., Oehlenschlager, F., Buehner, M. (1995) „Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models“, Journal of Molecular Biology, 247(2), 360-372, available: /brokenurl#://WOS:A1995QP61000017.
     
  • Duschl, A., Muller, T., Sebald, W. (1995) „Antagonistic mutant proteins of interleukin-4“, Behring Inst Mitt, (96), 87-94, available: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.
     

1994 [ nach oben ]

  • Demchuk, E., Mueller, T., Oschkinat, H., Sebald, W., Wade, R.C. (1994) „Receptor-Binding Properties of 4-Helix-Bundle Growth-Factors Deduced from Electrostatic Analysis“, Protein Science, 3(6), 920-935, available: /brokenurl#://WOS:A1994NN55000009.
     
  • Muller, T., Dieckmann, T., Sebald, W., Oschkinat, H. (1994) „Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy“, Journal of Molecular Biology, 237(4), 423-436, available: /brokenurl#://WOS:A1994NF55400007.
     
  • Oschkinat, H., Muller, T., Dieckmann, T. (1994) „Protein-Structure Determination with 3-Dimensional and 4-Dimensional Nmr-Spectroscopy“, Angewandte Chemie-International Edition in English, 33(3), 277-293, available: /brokenurl#://WOS:A1994MX73200002.
     
  • Muller, T., Sebald, W., Oschkinat, H. (1994) „Antagonist Design through Forced Electrostatic Mismatch“, Nature Structural Biology, 1(10), 674-676, available: /brokenurl#://WOS:A1994QN60600006.
     

1993 [ nach oben ]

  • Kruse, N., Shen, B.J., Arnold, S., Tony, H.P., Muller, T., Sebald, W. (1993) „2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation“, Embo Journal, 12(13), 5121-5129, available: /brokenurl#://WOS:A1993MM12000024.
     
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